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HORIZON EUROPE TOPIC · Cluster 6 · Food, Bioeconomy, Natural Resources, Agriculture and Environment

Replacing hazardous substances in biocidal products

HORIZON-CL6-2027-01-ZEROPOLLUTION-01 — the expected outcomes as checkable statements, what evaluators look for in this topic, and the conditions that shape the proposal.

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ForthcomingRIA · lump sumDeadline 22 September 2027around EUR 4 million per project

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TopicHORIZON-CL6-2027-01-ZEROPOLLUTION-01
StatusForthcoming
CallHORIZON-CL6-2027-01 — Call 01 - single stage (2027)
DestinationClean environment and zero pollution (2026-27)
Type of actionResearch and Innovation Actions · lump sum
Opening20 April 2027
Deadline22 September 2027
Budgetaround EUR 4 million per project · 3 projects expected · EUR 12 million in total
TRL at the endTRL 4–5
Part B page limit45 pages (standard application form; check your call)
TemplateWork Programme 2026–2027 application form

Expected outcomes

Projects should contribute to all of the expected outcomes. The topic says: “Project results are expected to contribute driving the innovation of public authorities and industrial operators confronted with the Biocidal products regulation (EC) No 528/2012, within the 'safe and sustainable by design' framework. The outcomes should support the goals of the Commission communication on: Building the future with nature: Boosting Biotechnology and Biomanufacturing in the EU,…”

  1. EO1 innovation in bio-based and natural substances brings safer alternatives to hazardous substances contained in biocidal products, with decreased risk on human health and biodiversity, including pollinators.
  2. EO2 safe, sustainable and effective solutions are developed and tested for the control of harmful organisms affecting human or animal health or the environment.

Expected impacts named in the destination

The wider, long-term effects the destination seeks. Your outcomes feed them; they are not project deliverables.

  1. EI1 Advancing scientific understanding and innovative solutions for identifying, preventing and mitigating pollution aim to effectively protect human health and safeguard the environment, preserving cleaner water and seas, healthier air and soil, and resilient forests.
  2. EI2 Innovative circular bio-based systems and biotechnologies are developed and made available to all stakeholders to progress towards the clean environment and zero-pollution ambition.
  3. EI3 Farmers and other actors in the food chain are empowered to make informed decisions and to apply novel strategies to prevent, reduce and remediate pollution from agriculture and the food system, contributing to the zero-pollution ambition.
  4. EI4 Effective solutions to remediate and decontaminate aquatic pollution are developed, made available and implemented contributing to reducing pollution to levels no longer considered harmful to the environment.

What evaluators will look for in this topic

Expected outcomes

  • Projects should contribute to all of the expected outcomes.
  • For each outcome (EO1 to EO2), name who will use or adopt your results (a specific group, not “industry” or “society”), how they get them, and the indicator that shows the change, with baseline, target and date.
  • Use the topic's own words for each outcome, so the evaluator can tick it off.

What the scope asks for

Evaluators check the proposal against these sentences of the scope. Answer each one visibly, in the call's own words.

  • “Proposals should:. develop innovative and Safe and Sustainable by Design (SSbD) bio-based substances to effectively replace hazardous active substances used in biocidal products covered by Biocidal products regulation and, specifically, at least in one of the following applications as listed below: hazardous active substances used in wood preservatives biocidal products.”
  • “Developed solutions/substances should aim to limit the development of resistance or cross-resistance to harmful organisms, such as Aspergillus species, and in particular Aspergillus fumigatus;. hazardous active substances used in insecticides biocidal products to control mosquitos.”
  • “Developed solutions/substances should be sufficiently effective to control larvae or adults of mosquitoes responsible for diseases transmitted to humans or animals;. the developed substances can include active substances derived from plants, microbes and other natural sources, and bio-based substances;. include a review at international level of the hazardous active substances in the scope (wood preservatives and insecticides to control…”
  • “Projects should include social sciences and humanities (SSH) in testing the safety of the developed substances on humans, especially including the analysis of groups in vulnerable situations, and the diversity in terms of sex, disability, age, race or ethnicity, religion or belief, gender, etc.”
  • “International cooperation is encouraged, for the review of substances in scope.”
  • “Participation of SMEs in the consortium is encouraged.”

Conditions that shape the proposal

  • Part B, sections 1–3: 45 pages (standard application form). Text beyond the limit is not read; tables and figures count.
  • Lump sum: the budget is fixed per work package and paid when each work package is completed. Every work package needs activities and deliverables an evaluator can verify, and the effort must match the money.
  • TRL: the topic expects TRL 4–5 by the end of the project. State where you start and the evidence for it.
  • Legal and financial set-up of the grants: “Beneficiaries may provide financial support to third parties. The support to third parties can only be provided in the form of grants. The maximum amount to be granted to each third party is EUR 60 000.”

Impact pathway and traps

  • The topic asks for social sciences and humanities (SSH) expertise. Evaluators look for SSH partners with a real role in the methodology, not a token task.
  • The scope expects pilots or demonstration. Name the sites, the partners who run them and what is measured there.
  • International cooperation is part of the scope. Explain what the non-EU partners add and how the cooperation is organised.
  • The gender dimension is named in the topic. Show how sex and gender analysis enters the research content, not only team balance.
  • Life-cycle or safe-and-sustainable-by-design assessment is expected. Name the method and where in the work plan it runs.
  • Policy or regulation is in scope. Name the policy owners you will reach and what you will give them.
  • Keep outputs, outcomes and impacts apart: what you deliver, what changes when others use it, and the long-term effect.
  • For each destination impact you claim, show which of your outcomes feeds it. Destination impacts are long-term effects, not project deliverables.
  • Name the barriers outside the project (regulation, markets, user behaviour) that could block uptake, and what you will do if they do.
  • Section 2.3 (the summary canvas) is optional on this call; the old split into scientific, economic and societal impact is no longer required.
The scope, as published

Despite being needed for the control of pests or harmful organisms, some of the biocidal active substances currently approved are problematic for human or animal health or the environment. More innovation to bring safer alternatives into the market is therefore essential, allowing for further restriction or ban to the use of the most hazardous biocidal active substances. Proposals should: develop innovative and Safe and Sustainable by Design (SSbD) bio-based substances to effectively replace hazardous active substances used in biocidal products covered by Biocidal products regulation and, specifically, at least in one of the following applications as listed below: hazardous active substances used in wood preservatives biocidal products. Developed solutions/substances should aim to limit the development of resistance or cross-resistance to harmful organisms, such as Aspergillus species, and in particular Aspergillus fumigatus; hazardous active substances used in insecticides biocidal products to control mosquitos. Developed solutions/substances should be sufficiently effective to control larvae or adults of mosquitoes responsible for diseases transmitted to humans or animals; the developed substances can include active substances derived from plants, microbes and other natural sources, and bio-based substances; include a review at international level of the hazardous active substances in the scope (wood preservatives and insecticides to control mosquitos); test the solutions/substances developed and assess their safety for human health, terrestrial and aquatic biodiversity, including pollinators; validate their contribution to biodiversity enhancement, when applicable; demonstrate their effectiveness in replacing the hazardous substances through scientific validated indicators, including their integration into final products, also in terms of cost-effectiveness. Projects should include social sciences and humanities (SSH) in testing the safety of the developed substances on humans, especially including the analysis of groups in vulnerable situations, and the diversity in terms of sex, disability, age, race or ethnicity, religion or belief, gender, etc. International cooperation is encouraged, for the review of substances in scope. Participation of SMEs in the consortium is encouraged.

Technology readiness, as published

Activities are expected to achieve TRL 4-5 by the end of the project – see General Annex B. Activities may start at any TRL. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022H2510. The SSbD framework is to be used to guide the innovation process towards safer and more sustainable chemicals and advanced materials. The application of the SSbD framework should be evidenced/visible…

Other topics in HORIZON-CL6-2027-01

Source and attribution

Topic text from the official topic page on the EU Funding & Tenders Portal, retrieved 19 October 2026. © European Union, reused under Commission Decision 2011/833/EU (CC BY 4.0). Changes: the expected outcomes and impacts are split into numbered statements, long passages are shortened, and the evaluator checklist is GrantWise's own commentary. Your call and the Work Programme always win; check them before you submit. GrantWise is independent and not affiliated with, endorsed by, or acting on behalf of the European Commission.